2008年02期目次

  • Effect of TCM Treatment on Quality of Life in Diabetic Nephropathy Patients with Renal Failure: A Multi-Centered Clinical Study

    ZHANG Li-fen, LV Ren-he, ZHAO Jin-xi, et al.(1. Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700)

    Objective To observe the effect of TCM treatment on quality of life in the patients of diabetic nephropathy (DN) with renal failure. Methods Multi-centered randomized-controlled, single-blinded design was carried out. The selected 221 diabetic nephropathy patients were randomized into TCM treatment group, Losartan group, and TCM treatment + Losartan group. Use WHO QOL-BREF and DQOL before treatment and 3 months after treatment respectively to evaluate the quality of life (QOL). Results All the treatment plans could increase the scores of QOL and self-scoring and decrease the influence of disease on physiological function and psychological state. Compared with before treatment, there was a significant difference (P<0.05 or P<0.01). Among all the three groups, there was a significant difference in self-scoring of patients before and after treatment(P<0.05). There was no significant difference among groups in changes of other scores of QOL after treatment(P>0.05). The result of intention-to-treat (ITT) analysis and PP analysis accorded with each other. Conclusion The TCM treatment based on the diet, glucose control, and symptomatic treatment can improve the quality of life of the patients with diabetic nephropathy. The TCM treatment may have advantage in increasing the self-scoring of patients.

    2008 02 [Abstract][OnlineView][Download 111K]

  • Clinical Observation on Acupuncture plus Chinese Medicine for 32 Cases of Vascular Headache

    HE Qing-yong1, LIANG Jun2, ZHANG Yue2, et al.(1. Guang'anmen Hospital,China Academy of Chinese Medical Sciences, Beijing 100053; 2. Acupuncture College of Beijing University of Chinese Medicine)

    Objective To observe the effect of acupuncture plus Chinese medicine and only Chinese medicine on vascular headache. Methods The 62 cases were randomized into treatment group (n=32 ) and control group (n=30). The treatment group was treated with acupuncture plus oral taking Chinese medicine and the control group simply with oral taking Chinese medicine. The therapeutic effect and score of headache were observed in both groups. Results The total effect of treatment group was better than that of control group (P<0.05). After treatment, both groups were improved in decreasing the frequency of headache, the days of headache attacks, lasting time of each attack and degree of headach(P<0.01). In decreasing the severity of headache, the treatment group was remarkably better than that of the control group (P<0.05). Conclusion Acupuncture plus oral taking Chinese medicine significantly effective for vascular headache.

    2008 02 [Abstract][OnlineView][Download 70K]

  • Clinical Observation on the Effect of Peritoneoscope Operation plus Chinese Medicine for 34 Endometriosis Patients

    WANG Xi-bo, LIU Xin, LIU Lin, et al.(People's Hospital of Weifang City, Shandong 261041)

    Objective To observe the effect of Bushen Huoxue Jiedu Recipe(decoction for reinforcing the kidney, activating the blood, and removing toxins) on the endometriosis patients after peritoneoscope operation. Methods The 96 patients were randomized into 3 groups. Western medicine was administered gestrinone, Chinese medicine group was given Bushen Huoxue Jiedu Recipe, and control group was not medicated. Their clinical effect and pregnant situation were observed. Results The complete remission rate of pains and signs of the two treated groups was higher and the accumulated relapse rate was lower than that of control group. The difference of within 2-year pregnancy rate of Chinese medicine group and control group was significant(P<0.05). Although the difference of pregnancy rate of the two treated groups was not significant(P>0.05), the pregnancy rate was high (72.73% and 45% respectively). Conclusion The effect of Bushen Huoxue Jiedu Recipe on the endometriosis was obvious, especially for those who are complicated with sterility, being the first choice for the treatment of endometriosis.

    2008 02 [Abstract][OnlineView][Download 64K]

  • Clinical Observation on 28 Cases of the Metabasis of Stomach Cancer after Operation Treated by Yiqi Bushen Oral Liquid and Chemotherapy

    LIU Yun-xia, JIANG Shen-jun, KUANG Tang-hong, et al.(The Third People's Hospital of Hangzhou City, Zhejiang 310009)

    Objective To study the effect of Yiqi Bushen (Reinforce qi and strengthen kidney) Oral Liquid and chemotherapy on the metabasis of stomach cancer after operation. Methods The 47 patients of stomach cancer after operation with the spleen and kidney deficiency syndrome were randomized into treatment group (n=28) and control group (n=19). The control group was treated simply by chemotherapy and the treatment group by chemotherapy and Yiqi Bushen Oral Liquid. Condition of relapse and metabsis, quality of life, peripheral blood examination and immune function were observed 12 months later. Results The relapse and metabasis rate of treatment group was remarkably lower than that of control group (P<0.05), the Karnofsky score, peripheral blood and immune function were all remarkably improved in comparison with control group (P<0.01 or P<0.05). Conclusion Yiqi Bushen Oral Liquid together with chemotherapy has a good function in resisting the metabasis of stomach cancer after operation and increasing the sensitivity and decreasing the untoward reactions, and improving quality of life and immune function of patients as well.

    2008 02 [Abstract][OnlineView][Download 361K]

  • Anti-inflammation Effect of Jianwei Yuyang Granule on Helicobacter Pylori Positive Peptic Ulcer Patients

    LING Jiang-hong1, HUANG Li-ping1, LI Jia-bang2, et al.(1. The First Affiliated Hospital of Guangxi Medical University, Nanning 530021; 2. Xiangya Hospital of Centre-South University)

    Objective To observe the effect and mechanism of Jianwei Yuyang (Strengthen the stomach to heal the ulcer) Granule on peptic ulcer (PU) patients. Methods Totally 46 Hp-positive PU patients were randomized into treatment group (treated with Jianwei Yuyang Granule) and control group (treated with western medicine). Before and after treatment, the inflammation degree of gastric antrum was determined with HE staining and the expression of NF-κB and β-defensin-2 in the gastric mucosa was tested by immunohistochemistry respectively. Results Jianwei Yuyang Granule significantly relieved the chronic inflammation and active degree of gastric antrum (P<0.01 and P<0.05 respectively), inhibited the activation of NF-κB, and down-regulated the increased expression of NF-κB and β-defensin-2 (P<0.01 or P<0.05). Conclusion Jianwei Yuyang Granule plays a role in anti-inflammation in promoting the healing of PU possibly through inhibiting the activation of NF-κB and decreasing the over-expression of β-defensin-2.

    2008 02 [Abstract][OnlineView][Download 836K]

  • Clinical Value of Peripheral Vessel Diagnostic System on TCM Syndrome Differentiation of Diabetes

    QI Hong, XIN Yan(TCM Hospital of Jinan City, Shandong 250012)

    Objective To observe the relation between functions of vessels of lower extremities and TCM syndromes differentiation in diabetes patients. Methods Totally 168 diabetics of Type II were differentiated into 5 syndromes, i.e. 29 cases of yin deficiency with excessive heat, 41 cases of qi and yin deficiency, 30 cases of yin and yang deficiency, 37 cases of blood stasis in channels, and 31 cases of damp heat affecting the spleen, and 26 healthy people were involved in the control group. The peripheral vessel diagnostic system was adopted to get the toe photoplethysmogram (PPG) and ankle brachial index (ABI) to observe the blood perfusion of limb terminals and the functional state of lower limb arteries. The relation between function of vessels of lower extremities and TCM syndrome was analyzed. Results All the diabetic groups were related with the arterial blood supply of toe terminals. Diabetes was the main risk factor in affecting the terminal blood supply (P<0.05), of which, the blood stasis in channels was the first risk factor, then it was the damp heat affecting the spleen, the yin and yang deficiency, the qi and yin deficiency, and the yin deficiency with excessive heat. The difference of ABI between the healthy control group and all the five patterns was significant(P<0.05 or P<0.01). Conclusion The substantial pathogens such as blood stasis and damp turbidity are playing the important role in the vessel diseases of lower limbs of diabetes and deficiency is the basis of vessel diseases of lower limbs.

    2008 02 [Abstract][OnlineView][Download 80K]

  • Effect of the Acupuncture Method "Regulating the Sea of Marrow, Circulating Yang and Soothing Tendon" on Quality of Life and Activity of Daily Living in Hemiplegia Patients

    LIU Zhi-shun1, WANG Li-ping2, YANG Guang3, et al.(1. Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053; 2. Huguosi TCM Hospital Affiliated to Beijing University of Chinese Medicine; 3. Beijing Xuanwu TCM Hospital)

    Objective To evaluate the effect of the acupuncture method "regulating the sea of marrow,circulating yang and soothing tendon" on quality of life (QOL) and activity of daily life(ADL) in hemiplegia patients. Methods Totally 400 hemiplegia patients were randomized into the treatment group(by the method of regulating the sea of marrow) and the control group(by standard acupuncture). Prospective, multi-centered, randomized-controlled, and single-blinded method were used. Barthel Index (BI) and WHO QOL-100 were selected to evaluate QOL and ADL. Results BI and improvement of disabled activities of both groups were significantly improved while the effect of treatment group was better. In addition, the scores of WHO QOL-100 and stroke-specific quality of life scale of both groups were also increased and the effect of treatment group was superior to that of control group. Conclusion The acupuncture method of "regulating the sea of marrow,circulating yang and soothing tendon" can significantly improve ADL and QOL of hemiplegia patients.

    2008 02 [Abstract][OnlineView][Download 104K]

  • Analysis on the Monoamine Neurotransmitters in Hypothalamus of Rat Models of Liver-qi Stagnation Syndrome

    ZHANG Hui-yun, QIAO Ming-qi, SUN Li(Shandong University of Traditional Chinese Medicine, Jinan 250355)

    Objective To study the mechanism of liver-qi stagnation syndrome of rat models. Methods The binding method was used to make rat models of liver-qi stagnation syndrome and the quantitative changes of hypothalamus norepinephrine (NE), epinephrine (E), dopamine (DA), and 5-hydroxytryptamine (5-HT) before and after modeling were determined with reversed phase ion pair (RP-IP)-HPLC. Results The level of E, DA and 5-HT was remarkably increased (P<0.05 or P<0.01) while NE decreased significantly (P<0.01), and they were all improved after medication. Conclusion The liver-qi stagnation syndrome is closely related with level of hypothalamus NE, E, DA and 5-HT.

    2008 02 [Abstract][OnlineView][Download 69K]

  • Distribution of TCM Syndromes in the Diabetic Neuropathy

    GAO Chang-yu1, HAN Shu-fen2, DUAN Wei-song1, et al.(1. The Second Affiliated Hospital of Hebei Medical University, Shijiazhuang 050000; 2. TCM Diagnosis Teaching and Researching Section of Hebei Medical University)

    Objective To study the distribution features of TCM syndromes in the diabetic neuropathy. Methods Totally 114 diabetics with neuropathy were differentiated and classified according to the criteria of TCM syndrome differentiation. Results (1)The incidence of simple syndrome of Qi deficiency syndrome, fire-heat syndrome, blood stasis syndrome, yin deficiency syndrome, yang deficiency syndrome, phlegm damp syndrome, and blood deficiency syndrome was 49.12%,38.59%,36.84%,27.19%,14.91%,8.77% and 0.88% respectively. (2)At the first stage of diabetic neuropathy, the incidence of qi deficiency and fire-heat syndromes was higher (67.65%, 32.35%); at the second stage, the incidence of blood stasis, yin deficiency and yang deficiency syndromes was obviously increased (52.11%, 26.76%, 11.27%); at the third stage, the incidence of yin deficiency and yang deficiency syndromes increased to the utmost (both 100%). (3)At the first stage of diabetic neuropathy, the incidence of simple syndrome was 67.65%; at the second stage, the incidence of two syndromes combined was 57.75%; and at the third stage, the incidence of three syndromes combined was 55.56%. (4)There were 15 forms of combinated syndromes. At the first stage of diabetic neuropathy, the incidence of qi deficiency and fire-heat syndromes was higher (35.3%, 32.4%). At the second stage, the incidence of fire-heat and blood stasis syndrome, fire-heat syndrome, and qi deficiency and blood stasis syndrome was higher (19.7%, 18.3%, 14.1%), while at the third stage, the incidence of yin-yang deficiency and blood stasis syndrome was higher (55.6%). Conclusion The qi deficiency syndrome, fire-heat syndrome, blood stasis syndrome, yin deficiency syndrome, yang deficiency syndrome and phlegm damp syndrome are the basic syndromes of diabetic neuropathy and they are related with the development of pathological conditions.

    2008 02 [Abstract][OnlineView][Download 96K]

  • Preliminary Study on the Doppler Blood Flow Analysis of Blood-stasis Tongue

    XU Zhi-wei, CHEN Qun, CHAI Ya-qian, et al.(Guanghzou University of Chinese Medicine, Guangzhou 510405)

    Objective To study the relation between tongue blood flow and tongue of phlegm retention with blood stasis and tongue of qi deficiency with blood stasis. Methods The colored Doppler flow imaging (CDFI) was applied to test the blood flow of deep artery and vein of tongues of 41 phlegm retention with blood stasis patients, 40 qi deficiency with blood stasis patients, and 43 normal people for the comparison analysis. Results There was a significant difference in the maximum flow speed, minimum flow speed, average flow speed, resistance index, and throbbing index of deep artery of tongue (P<0.05, P<0.01). The group of blood stasis tongue was manifested as decreased blood flow speed, increased resistance index and throbbing index, thus there was a high resistance and low speed of blood flow. Conclusion The throbbing index of deep artery of tongue of Qi deficiency with blood stasis group was lower than that of tongue of phlegm retention with blood stasis group, and the blood flow speed of these two groups was lower than that of normal tongue group. The microcirculation disturbance of tongue may be one of the important factors in forming the blood stasis tongue.

    2008 02 [Abstract][OnlineView][Download 75K]

  • Effect of Huangqi (Astragalus) on the Proliferation and Cell Cycle of Endothelial Progenitor Cells of Human Peripheral Blood

    XU Han-song1, LEI Min-xiang2, LIU Ze-hao2, et al.(1. The Second Affiliated Hospital of Guiyang College of Traditional Chinese Medicine,Guizhou 550003; 2.Xiangya Hospital of Centre-south University)

    Objective To study the effect of Huangqi (Radix Astragali seu Hedysari) on the proliferation and cell cycle of endothelial progenitor cells (EPCs) of human peripheral blood. Methods The mononuclear cells were isolated from human peripheral blood by density gradient centrifugation. After 7 days' culture, the anchorage-dependent cells were collected and the Huangqi Injectio (0.2, 2, 20 and 200mg/ml) was injected for intervention (for 6, 12, 24 and 48h). The laser scanning confocal microscope was used to determine the EPCs of human peripheral blood, the methyl thiazolyl tetrazoliym (MTT) assay was applied to test the proliferation of EPCs in vitro, and the flow cytometry (FCM) was adopted to detect the changes of cell cycle. Results Huangqi promoted the proliferation of EPCs remarkably, showing a time- and dose-effect relation. The FCM analysis showed that the S-phase and G2/M-phase rate increased but G0/G1-phase rate decreased relatively (P<0.01). Conclusion Huangqi functions to promote the proliferation of EPCs remarkably and its mechanism may be promoting DNA synthesis and increasing the number of cells entering S-phase.

    2008 02 [Abstract][OnlineView][Download 107K]

  • Effect of Naomaitong on the Time Window of Thrombolysis through Artery for the Cerebral Ischemic Rats with Thrombo-Embolism

    LI Jian-sheng1, WANG Dong2, LIU Jing-xia3, et al.(1. Geriatrics Institute of Henan University of Traditional Chinese Medicine, Zhengzhou 450003; 2. Women and Children Care Centre of Luoyang City; 3. Beijing University of Chinese Medicine)

    Objective To study the protective effect and influence of Naomaitong (Remove obstruction of cerebral vessels) on the time window of thrombolysis for the cerebral ischemic rats with thrombo-embolism. Methods The rats were randomized into sham-operated group, model group, urokinase (UK) thrombolysis group, Naomaitong group, and UK plus Naomaitong group (associated group). The cerebral ischemic rat models with thrombo-embolism were made by blocking sylvian artery. The rats were administrated local thrombolysis with duct to artery at the time-point of 3, 6, and 9h after cerebral ischemia. At 24h of administration through artery, the pathologic changes of brain and the symptoms of nerve system were observed to determine the brain water ratio (BWR) and the change of cerebral infarction area (CIA). Results Compared with the sham-operated group, in all model groups, the score of nerve system symptoms increased, the BWR and CIA increased, and the brain pathological changes became worse; in all thrombolysis groups, the score of nerve system symptoms decreased, the BWR and CIA decreased, and the brain pathologic changes became relieved; within 6 hours, the improvement of above-mentioned thrombolysis indices was especially remarkable; in the associated group, all indices at the corresponding time-point were improved significantly than those of the thrombolysis group and Naomaitong group. Conclusion Thrombolysis through artery given at different time is protective for the ischemic tissues, but the effect of treatment given at 3 and 6h after ischemia is better than that of 9h. Naomaitong enhances the protection, functioning to prolong the time window of thrombolysis.

    2008 02 [Abstract][OnlineView][Download 109K]

  • Effect of Huangqi Injectio on Abnormal Expression of Aquaporin-1 Caused by Glucose Lactate Peritoneal Dialysis Solution

    WANG Yi1, SHU Jing1, HU Weihua2(1. Yueyang Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai 200437; 2. Haici Hospital of Qingdao City)

    Objective To observe the effect of Huangqi (Radix Astragali seu Hedysari) Injectio on the abnormal expression of aquaporin-1 (AQP-1) caused by glucose lactate peritoneal dialysis solution. Methods Different glucose concentration lactate peritoneal dialysis solutions and Huangqi Injectio given to the rats intraperitoneally. Eight weeks later, the ultrafiltration of peritoneal dialysis, peritoneum clearance, peritoneal structure, AQP-1 and its gene expression were observed. Results Compared with the control group, in the glucose and Huangqi groups, the ultrafiltration of peritoneal dialysis was remarkably decreased (P<0.05); in the high glucose group, urea nitrogen clearance was remarkably lower (P<0.05). After the dialysis, the injuries of peritoneal structure in different degrees existed, especially worse in the high glucose group. The AQP-1 expression in the high glucose and high Huangqi group was remarkably decreased in comparison with the control group (P<0.05). Conclusion The Huangqi Injectio can protect the peritoneum, but its definite function on the AQP-1 expression is not yet determined.

    2008 02 [Abstract][OnlineView][Download 82K]



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